Takebe.Lab

PUBLICATIONS

Article

2020

Polygenic architecture informs potential vulnerability to drug-induced liver injury

Nature Medicine | in press

Koido et al. revealed genetically defined hepatocyte vulnerability mechanisms to currently unpredictable drug induced liver injury supported by cell-, organoid- and patient-level datasets.

Koido M, Kawakami E, Fukumura J, Noguchi Y, Ohori M, Nio Y, Nicoletti P, Aithal G, Daly, A, Watkins P, Anayama H, Dragan Y, Shinozawa T & Takebe T

Methods in Cell Biology | 22 May

Wendy elaborated a human liver organoid culture protocol based on Ouchi et al. Cell Metabolism paper in 2019.

Wendy L. Thompson, Takanori Takebe

bioRxiv | Posted 21 April

Han et al. identified  unexpected diversity in mesoderm-derivatives during early foregut organogenesis. This study is highly collaborative work with  Aaron Zorn group and Mitsuru Morimoto group at RIKEN.

Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C Witcher, Alexandra Eicher, Lauren Haines, Yarim Lee, John M Shannon, Mitsuru Morimoto, James M Wells, Takanori Takebe,  Aaron M Zorn

European Journal of Cardio-Thoracic Surgery | 7 April

Okabe et al., in collaboration with thoracic surgeons at Kyoto, extended fetal organ bud transplantation approach towards acute lung injury protection in mouse model.

Ryo Okabe, Toyofumi F Chen-Yoshikawa, Akihiko Yoshizawa, Tsuyoshi Hirashima, Masao Saito, Hiroshi Date, Takanori Takebe

2019

Cell Metabolism | May 30

Ouchi et al. established a method to generate multicellular organoid models of inflammation and fibrosis that can be used for genetic steatohepatitis modeling. 

Ouchi, R., Togo, S., Kimura, M., Shinozawa, T., Koido, M., Koike, H., Thompson, W., Karns, R. A., Mayhew, C. N., McGrath, P. S., McCauley, H. A., Zhang, R. R., Lewis, K., Hakozaki, S., Ferguson, A., Saiki, N., Yoneyama, Y., Takeuchi, I., Mabuchi, Y., Akazawa, C., Yoshikawa, H. Y., Wells, J. M., Takebe, T.*

Featured in Nature Reviews
Featured in NIH Director’s Blog

 

Nature | 25 September

Koike et al. established a multi-organ connection in human stem cell derived organoid model amongst liver, biliary, pancreatic and duodenal tissues.

Koike, H., Iwasawa, K., Ouchi, R., Maezawa, M., Giesbrecht, K., Saiki, N., Ferguson A., Kimura, M., Thompson, W., Wells, J. M., Zorn, A. M. & Takebe, T.

Science | June 2019

Discussed current and future of designing complex organoids.

Takanori Takebe*, James M. Wells

Nature Medicine | 2019

Invited mini-personal story. 

Takanori Takebe

ACS Nano | 4 December

Fang et al. designed a low-toxicity, photostable, near-infrared small molecule fluorescence probe HD-Br for use in the super-resolution imaging of lysosomes.

Fang, H., Yao, S., Chen,Q., Liu, C., Cai, Y., Geng, S., Bai, Y., Tian, Z., Zacharias, A. L., Takebe, T., Chen, Y., Guo, Z., He, W., and Diao, J.

2018

Stem Cell Reports | 9 October

Takahisa Matsuzaki, Shinya Matsumoto, Toshiharu Kasai, Hiroshi Y. Yoshikawa, Hideki Taniguchi, Takanori Takebe

Stem Cell Reports | September 2019

Hiroaki Ayabe, Takahisa Anada, Takuo Kamoya, Tomoya Sato, Masaki Kimura, Emi Yoshizawa, Shunyuu Kikuchi,  Yasuharu Ueno, Keisuke Sekine,  Gray Camp, Barbara Treutlein, Autumn Ferguson, Osamu Suzuki, Takanori Takebe, Hideki Taniguchi

iScience | 31 May

Masaki Kimura, Momoko Azuma, Ran-Ran Zhang, Wendy Thompson, Christopher N. Mayhew, Takanori Takebe

Cell Reports | 8 May

Yoshinobu Takahashi, Keisuke Sekine, Tatsuya Kin, Takanori Takebe, Hideki Taniguchi

Selected as cover article

Stem Cell Reports | 13 March

Ran-Ran Zhang, Masaru Koido, Tomomi Tadokoro, Rie Ouchi, Tatsuya Matsuno, Yasuharu Ueno, Keisuke Sekine, Takanori Takebe, Hideki Taniguchi

Hepatology | 19 February

Kyle Lewis, Takanori Takebe

2017

Cell Reports | 5 December

Takanori Takebe, Keisuke Sekine, Masaki Kimura, Satoshi Okamoto, Yasuharu Ueno, Hideki Taniguchi

Cell Stem Cell | 7 September

Takanori Takebe, Boyang Zhang, Milica Radisic

Cell Stem Cell | Q&A | 1 June

Hans Clevers, Madeline Lancaster, and Takanori Takebe

Development | 14 March

Hiroyuki Koike, Ran-Ran Zhang, Yasuharu Ueno, Keisuke Sekine, Yun-Wen Zheng, Takanori Takebe, Hideki Taniguchi

Nature | 14 June

J. Gray Camp, Keisuke Sekine, Tobias Gerber, Henry Loeffler-Wirth, Hans Binder, Malgorzata Gac, Sabina Kanton, Jorge Kageyama, Georg Damm, Daniel Seehofer, Lenka Belicova, Marc Bickle, Rico Barsacchi, Ryo Okuda, Emi Yoshizawa, Masaki Kimura, Hiroaki Ayabe, Hideki Taniguchi, Takanori Takebe & Barbara Treutlein

Featured in Science
Featured in Cell Systems

2016

Developmental Biology | 15 December

Tadahiro Shinozawa, Hiroshi Y. Yoshikaw, Takanori Takebe

Reviews in Cell Biology and Molecular Medicine | November

Hiroyuki Koike, Tamir Rashid, Takanori Takebe

Cell Transplantation | 1 May

Shintaro Kagimoto, Takanori Takebe, Shinji Kobayashi, Yuichiro Yabuki, Ayaka Hori, Koichi Hirotomi, Taro Mikami, Toshimasa Uemura, Jiro Maegawa, Hideki Taniguchi

Regenerative Therapy | March

Yoshinobu Takahashi, Takanori Takebe, Hideki Taniguchi

Current Pathobiology Reports | 11 April

Hiroyuki Koike & Takanori Takebe

2015

Cell Stem Cell | 7 May

TakanoriTakebe, Masahiro Enomura, Emi Yoshizawa, Masaki Kimura, Hiroyuki Koike, Yasuharu Ueno, Takahisa Matsuzaki, Takashi Yamazaki, Takafumi Toyohara, Kenji Osafune, Hiromitsu Nakauchi, Hiroshi Y.Yoshikawa, Hideki Taniguchi

Selected as Cover Article
Best of Cell Stem Cell, 2015
News and Views in Cell Stem Cell
Featured in Nature Methods

Nature | News Feature | 29 July

Cassandra Willyard

2014

Journal of Clinical Investigation | 9 September

Takanori Takebe, Shinji Kobayashi, Hiromu Suzuki, Mitsuru Mizuno, Yu-Min Chang, Emi Yoshizawa, Masaki Kimura, Ayaka Hori, Jun Asano, Jiro Maegawa, and Hideki Taniguchi

Stem Cells and Development | 2 September

Rashid T, Takebe T, Nakauchi H.

STEM CELLS | 23 August

Mitsuru Mizuno, Shinji Kobayashi, Takanori Takebe, Hiroomi Kan, Yuichiro Yabuki, Takahisa Matsuzaki, Hiroshi Y. Yoshikawa, Seiichiro Nakabayashi, Lee Jeong Ik, Jiro Maegawa, Hideki Taniguchi

Organ Biology | 10 July

Yoshinobu Takahashi, Takanori Takebe, Hideki Taniguchi.

Stem Cells and Development | 26 June

Yun-Wen Zheng, Tomonori Tsuchida, Taiki Shimao, Bin Li, Takanori Takebe, Ran-Ran Zhang, Yu Sakurai, Yasuharu Ueno, Keisuke Sekine, Naoto Ishibashi, Makiko Imajima, Takuji Tanaka, and Hideki Taniguchi

Clinical Pharmacology & Therapeutics | 21 May

T Takebe, H Taniguchi.

Hepatology | 4 February

Hiroyuki Koike, Yasuharu Ueno, Takako Naito, Tomoya Shiina, Susumu Nakata, Rie Ouchi, Yuta Obana, Keisuke Sekine, Yun‐Wen Zheng, Takanori Takebe, Kyo‐ichi Isono, Haruhiko Koseki, Hideki Taniguchi

Nature Protocols | 23 January

Takanori Takebe, Ran-Ran Zhang, Hiroyuki Koike, Masaki Kimura, Emi Yoshizawa, Masahiro Enomura, Naoto Koike, Keisuke Sekine & Hideki Taniguchi

Organogenesis | 22 January

Takanori Takebe, Naoto Koike, Keisuke Sekine, Ryoji Fujiwara, Takeru Amiya, Yun-Wen Zheng  & Hideki Taniguchi

2013

Nature | 03 July

Takanori Takebe, Keisuke Sekine, Masahiro Enomura, Hiroyuki Koike, Masaki Kimura, Takunori Ogaeri, Ran-Ran Zhang, Yasuharu Ueno, Yun-Wen Zheng, Naoto Koike, Shinsuke Aoyama, Yasuhisa Adachi & Hideki Taniguchi

Selected as Breakthrough of the Year, 2013 in Science

Selected as World top 5 discovery in Discover magazineNews and Views in NatureFeatured in Science, Nature Medicine, Cell Stem Cell, Hepatology, Gastroenterology, Cell Research, etc…

Press in BBC, The Economist, Scientific American, The Guardian, etc…​

Biomaterials | July

Hiroyasu Tanaka, Shin Tanaka, Keisuke Sekine, Sayaka Kita, Ai Okamura, Takanori Takebe, Yun-Wen Zheng, Yasuharu Ueno, Junzo Tanaka, Hideki Taniguchi

Organ Biology | 10 July

Takanori Takebe, Hideki Taniguchi.

2012

BMC Biotechnology | November

Hiroyuki Koike, Koji Kubota, Keisuke Sekine, Takanori Takebe, Rie Ouchi, Yun-Wen Zheng, Yasuharu Ueno, Naoki Tanigawa, Hideki Taniguchi

Transplantation Proceedings | July

T Takebe, N Koike, K Sekine, M Enomura, Y Chiba, Y Ueno, Y-W Zheng, H Taniguchi

Nature | News Feature | 20 June

David Cyranoski

Transplantation Proceedings | May

T Takebe, K Sekine, Y Suzuki, M Enomura, S Tanaka, Y Ueno, Y-W Zheng, H Taniguchi

2011

PLOS ONE | 19 October

Shinji Kobayashi ,Takanori Takebe ,Yun-Wen Zheng,Mitsuru Mizuno,Yuichiro Yabuki,Jiro Maegawa,Hideki Taniguchi

PNAS | 30 August

Shinji Kobayashi, Takanori Takebe, Midori Inui, Sayaka Iwai, Hiroomi Kan, Yun-Wen Zheng, Jiro Maegawa, and Hideki Taniguchi

Book

2019 | Takanori Takebe . Japan, Yodosha Co., Ltd.ISBN 978-4-7581-2239-9

2019 |Takanori Takebe (2019) , Japan, Yodosha, ISBN 978-4-7581-2500-0

November 2016 | Koike H, Takebe T*. Growing Mini-Organs from Stem Cells. Wiley-VCH. Volume 2
Issue 4.

July 2015 | Ran-Ran Zhang, Hiroyuki Koike, Takanori Takebe, ‘The Visualization of Human Organogenesis from Stem Cells by Recapitulating Multicellular Interactions’, p. 275-283, 15

Media

June 2020 | Takanori Takebe. Japan. PRESIDENT Inc.

February 2020 | Takanori Takebe . Japan. The Asahi Shimbun Company.

January 2020 | Takanori Takebe. Japan. Newton Press Ltd.

November 2019 | Takanori Takebe, Ken Iwasawa. Japan. Medical Principle Co., Ltd.